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Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study

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Abstract

In the rat experimental model of posttraumatic stress disorder (PTSD), the level of blood corticosterone was at least eight-fold increased (an overrelease). The use of hypobaric hypoxic preconditioning or short-term inhibition of glucocorticoid synthesis by metyrapone injection prevented development of the experimental PTSD.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg, Russia

    M. Y. Zenko, K. A. Baranova & E. A. Rybnikova

Authors
  1. M. Y. Zenko
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  2. K. A. Baranova
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  3. E. A. Rybnikova
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Correspondence to E. A. Rybnikova.

Additional information

Original Russian Text © M.Y. Zenko, K.A. Baranova, E.A. Rybnikova, 2018, published in Doklady Akademii Nauk, 2018, Vol. 479, No. 3, pp. 348–350.

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Zenko, M.Y., Baranova, K.A. & Rybnikova, E.A. Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study. Dokl Biol Sci 479, 51–53 (2018). https://doi.org/10.1134/S0012496618020059

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  • DOI: https://doi.org/10.1134/S0012496618020059

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